Table 2.
Univariate and multivariate analysis of factors significantly predictive of early local recurrence after achieving a complete response
| Variable |
Univariate analysis |
Multivariate analysis |
||||
| OR | 95%CI | P value | OR | 95%CI | P value | |
| Age (≥ 65 yr) | 0.489 | 0.233-1.026 | 0.058 | - | - | - |
| Sex (female) | 2.239 | 1.028-4.876 | 0.042 | 1.969 | 0.704-5.507 | 0.197 |
| Tumor number, multiple | 2.614 | 1.203-5.680 | 0.015 | 2.171 | 0.784-6.012 | 0.136 |
| Tumor size (cm) | ||||||
| 2-5 | 3.107 | 1.318-7.324 | 0.010 | 3.911 | 1.344-11.383 | 0.012 |
| > 5 | 9.000 | 2.401-33.738 | 0.001 | 5.218 | 1.056-25.767 | 0.043 |
| Child-Pugh score (≥ 8) | 2.773 | 0.785-9.788 | 0.113 | - | - | - |
| Decompensated LC | 0.830 | 0.385-1.788 | 0.634 | - | - | - |
| Gelfoam or PVA use | 1.487 | 0.662-3.340 | 0.336 | - | - | - |
| Bilirubin (> 2.0 mg/dL) | 3.351 | 0.623-18.030 | 0.159 | - | - | - |
| Albumin (< 3.5 mg/dL) | 1.550 | 0.732-3.284 | 0.252 | - | - | - |
| Post-CR AFP (> 20 ng/mL) | 2.362 | 1.023-5.456 | 0.044 | 3.464 | 1.262-9.507 | 0.016 |
| Lipiodol uptake (non-compact) | 9.342 | 2.916-29.929 | < 0.001 | 9.092 | 2.537-32.508 | 0.001 |
| TACE number to CR (≥ 2) | 2.765 | 1.105-6.924 | 0.030 | 2.029 | 0.715-5.756 | 0.715 |
AFP: α-fetoprotein; CR: Complete response; OR: Odds ratio; LC: Liver cirrhosis; PVA: Polyvinyl alcohol; TACE: Transcatheter arterial chemoembolization; PVT: Portal vein thrombosis.