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. 2014 Jun 11;34(24):8231–8245. doi: 10.1523/JNEUROSCI.0122-14.2014

Figure 1.

Figure 1.

Purkinje cell-specific removal of Vgat. A, In control animals (Vgatflox/flox), all vermis Purkinje cells (pcl) express Vgat. Inset, Vgat expression in the hemispheres. B, L7Cre deletes Vgat from Purkinje cells. Inset, Loss of Purkinje cell Vgat expression in the hemispheres. The arrows point to the Purkinje cell layer. C, Higher power image from the box in A. D, Higher power image from the box in B. L7Cre;Vgatflox/flox mutant mice lack Vgat mRNA expression specifically in Purkinje cells. In L7Cre;Vgatflox/flox mice, Vgat mRNA is still expressed in Golgi cells (open arrows) in the granular layer (gl) and in stellate and basket cell interneurons in the molecular layer (ml). Lobules are labeled with Roman numerals (Larsell, 1970). Scale bars: A, B, 200 μm; C, D, 20 μm.