Table 5.
Effects of BACE inhibition on APP metabolites' AUC57 from SILK and ELISA assays
| Dosage of BACE inhibitor | SILK MFL | ELISA concentration | Newly synthesized product (SILK % × ELISA) |
|---|---|---|---|
| Aβ (mean, SEM) | |||
| 10 mg/kg | 77.8 ± 6.4% | 111 ± 12.9% | 88.4 ± 13.2% |
| 30 mg/kg | 70.8 ± 7.0% | 58.6 ± 12.3% | 37.8 ± 11.5% |
| 125 mg/kg | 47.5 ± 6.2% | 33.2 ± 8.2% | 9.4 ± 3.8% |
| sAPPβ (mean, SEM) | |||
| 10 mg/kg | 84.4 ± 4.4% | 88.1 ± 2.1% | 71.3 ± 5.5% |
| 30 mg/kg | 78.3 ± 3.4% | 63.0 ± 2.7% | 42.1 ± 3.9% |
| 125 mg/kg | 69.9 ± 5.1% | 38.3 ± 4.4% | 17.6 ± 2.6% |
| sAPPα (mean, SEM) | |||
| 10 mg/kg | 99.6 ± 9.3% | 107.8 ± 7.4% | 108.3 ± 7.6% |
| 30 mg/kg | 101.0 ± 3.2% | 113.8 ± 5.8% | 123.1 ± 7.4% |
| 125 mg/kg | 101.5 ± 6.6% | 131.4 ± 6.9% | 134.6 ± 10.1% |