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Intranasal administration of anti-HMGB1 reduced AHR to methacholine stimuli. The Penh values represent the OVA-induced AHR to methacholine and were measured in mice from the control, asthma, control IgG-treated, and anti-HMGB1-treated groups using a body plethysmograph. The values represent the means ± standard deviations (n = 5). *P < 0.05 and **P < 0.01 compared with the asthma group.
