Table 4.
Summary of the potential regulatory effects of the SNVs between C57BL/6NJ and DBA/2J in genes demonstrating GxE interactions.
| NTC/NTO | Symbol | Gene | MMU | Coordinates | Strand | B6/D2 SNV | Altered TFB | Potential epigenetic gene regulation changes | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CpG Change | CG to NN | NN to CG | Altered TFB | ||||||||
| NTC | Csmd3 | CUB and Sushi multiple domains 3 | 15 | 47412184-48623535 | Reverse | 11 | 8 | 1 | 0 | 1 | 1 |
| NTC | Eya2 | Eyes Absent | 2 | 165420528-165597131 | Forward | 21 | 16 | 5 | 4 | 1 | 4 |
| Homolog2 (Drosophila) | |||||||||||
| NTC | Fam174b | Membrane protein | 7 | 80885193-80921805 | Forward | 1 | 0 | 0 | 0 | 0 | 0 |
| FAM174B precursor | |||||||||||
| NTC | Mageb18 | Melanoma-associated antigen | X | 89364218-89844911 | Forward | 1 | 1 | 0 | 0 | 0 | 0 |
| B18 | |||||||||||
| NTC | Mcat | Malonyl CoA:ACP | 15 | 83377227-83386141 | Reverse | 54 | 42 | 12 | 6 | 5 | 9 |
| Acyltransferase | |||||||||||
| (Mitochondrial) | |||||||||||
| NTC | Pdxp | Pyridoxal phosphate phosphatase | 15 | 78744349-78749947 | Forward | 18 | 14 | 9 | 5 | 4 | 8 |
| NTC | Rpl36a | 60S ribosomal protein L36a | X | 131120193-131122601 | Forward | 3 | 2 | 1 | 1 | 0 | 1 |
| NTC | Tac2 | Tachykinin-2 | 10 | 127162448-127168824 | Forward | 9 | 7 | 3 | 1 | 2 | 3 |
| NTC | Tspan2 | Tetraspanin-2 | 3 | 102538693-102576233 | Forward | 1 | 1 | 0 | 0 | 0 | 0 |
| NTC | Zfp157 | Zinc finger protein 157 | 5 | 138882704-138901922 | Forward | 5 | 3 | 2 | 2 | 0 | 1 |
| NTO | Apold1 | Apolipoprotein L | 6 | 134932019-134936854 | Forward | 51 | 43 | 12 | 6 | 6 | 11 |
| Domain Containing 1 | |||||||||||
| NTO | Leo1 | Paf1/RNA | 9 | 75289331-75314239 | Forward | 6 | 6 | 3 | 1 | 2 | 3 |
| Polymerase II | |||||||||||
| Complex Component | |||||||||||
| NTO | Psme4 | Proteasome (Prosome, Macropain) Activator | 11 | 30671775-30780361 | Forward | 16 | 10 | 2 | 1 | 1 | 2 |
| Subunit 4 | |||||||||||
| NTO | Snord38a | Small nucleolar RNA, C/D box 38A | 4 | 116827121-116827179 | Reverse | 32 | 24 | 8 | 4 | 3 | 7 |
| NTO | Vipr1 | Vasoactive Intestinal | 9 | 121551834-121582072 | Forward | 8 | 6 | 3 | 2 | 1 | 2 |
| Peptide Receptor 1 | |||||||||||
| NTO | Vps51 | Vacuolar protein sorting 51 | 19 | 6067842-6077187 | Reverse | 4 | 3 | 1 | 1 | 0 | 1 |
| Total | 241 | 186 | 62 | 34 | 26 | 53 | |||||