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DNA damage evaluated by the comet assay in white blood cells from mice injected (ip) with 37.5 μg/kg bw of MCLR, at several timepoints after treatment. Results are expressed as the mean percentage of DNA in comet tails (±SD) of 6 animals per treatment condition. The positive control, ethylnitrosourea (ENU) (100 mg/Kg), induced a 2- to 6-fold increase in the percentage of tail DNA. ∗represents a statistically significant difference between the treated and the control cells (P < 0.05).
