Figure 5.

Results of the micronucleus assay in reticulocytes (Ret) from mice injected (i.p.) with 37.5 μg/kg bw of MCLR. Results are expressed as the mean frequency of micronucleated reticulocytes (MNRet) (±SD) from 6 animals at several timepoints (primary axis). The negative control consisted of samples collected at 0 h. The positive control, ethylnitrosourea (100 mg/Kg), stimulated the increase of MNRet after 48 h (13-fold) and 72 h (2-fold) of exposure. In the secondary axis the percentage of reticulocytes was included. ∗represents a statistically significant difference between the treated and the control cells (P < 0.05).