Table 5.

Plasma angiogenesis-related biomarkers in subgroups of ALD patients according to the presence of the disease complications.

	Ascites						P
	Absent (n = 58)			Present (n = 89)
	Median	95% CI	25–75 P	Median	95% CI	25–75 P
Ang1 ng/mL	3.19	2.32–5.04	1.51–5.29	2.09	1.50–3.17	0.16–4.82	0.11
Ang2 ng/mL	3.21	2.52–3.88	1.88–4.58	7.53	5.35–9.43	3.89–11.40	<0.0001
VEGF-A pg/mL	100.22	82.63–196.53	61.40–333.36	68.73	58.66–86.55	29.43–149.34	0.031
	Hepatic encephalopathy
	Absent (n = 127)			Present (n = 20)			P
	Median	95% CI	25–75 P	Median	95% CI	25–75 P
Ang1 ng/mL	2.96	2.09–3.28	1.03–5.70	1.77	0.00–3.64	0.00–3.69	0.07
Ang2 ng/mL	4.45	3.64–5.26	2.92–8.84	10.13	5.61–14.87	4.83–15.16	0.0009
VEGF-A pg/mL	91.79	71.66–115.74	44.30–243.11	49.17	25.50–84.63	25.46–85.27	0.003
	Oesophageal varices
	Absent (n = 60)			Present (n = 87)			P
	Median	95% CI	25–75 P	Median	95% CI	25–75 P
Ang1 ng/mL	3.06	2.33–5.14	1.75–7.28	2.32	1.51–3.29	0.16–4.70	0.08
Ang2 ng/mL	3.63	2.89–5.26	1.88–6.21	5.12	4.37–8.31	3.55–11.46	0.001
VEGF-A pg/mL	100.22	72.73–231.94	61.98–358.65	71.66	52.43–89.51	26.62–146.57	0.005
	Cholestasis
	Absent (n = 117)			Present (n = 30)			P
	Median	95% CI	25–75 P	Median	95% CI	25–75 P
Ang1 ng/mL	2.32	1.51–3.05	0.49–5.08	4.72	3.28–6.40	2.90–7.28	0.002
Ang2 ng/mL	4.83	3.64–6.55	2.90–10.52	3.90	3.39–4.55	3.12–6.21	0.28
VEGF-A pg/mL	71.81	61.40–88.396	33.01–168.11	121.73	101.30–244.22	81.52–402.69	0.001
	Renal impairment
	Creatinine < 1.3 mg/dL (n = 125)			Creatinine ≥ 1.3 mg/dL (n = 22)			P
	Median	95% CI	25–75 P	Median	95% CI	25–75 P
Ang1 ng/mL	2.32	1.69–3.18	0.65–5.29	3.27	3.05–5.14	2.71–5.28	0.08
Ang2 ng/mL	4.45	3.63–5.12	2.92–9.06	9.42	7.13–11.40	5.09–11.99	0.004
VEGF-A pg/mL	73.79	66.81–91.62	33.74–231.66	112.68	85.52–158.08	64.60–207.91	0.32
	Disease outcome
	Survivors (n = 135)			Nonsurvivors (n = 12)			P
	Median	95% CI	25–75 P	Median	95% CI	25–75 P
Ang1 ng/mL	3.05	1.98–3.52	1.00–5.70	2.28	0.00–2.71	0.00–2.71	0.10
Ang2 ng/mL	4.51	3.80–5.26	2.92–8.92	11.74	9.48–13.44	9.48–13.44	0.001
VEGF-A pg/mL	85.270	68.73–95.69	40.84–207.31	73.14	25.46–246.83	25.46–246.83	0.48