Table 2.
Metabolic phenotype of males (top) and females (bottom), comparing control (IR flox) and OIRKO mice.
| Units | IR flox (n = 6) | OIRKO (n = 9) | P value | |
|---|---|---|---|---|
| Measurements (male) | ||||
| Final body weight | g | 24.7 ± 2.2 | 19.3 ± 2.0 | <0.001 |
| Fasting insulin | ng/mL | 0.14 ± 0.04 | 0.26 ± 0.22 | 0.24 |
| Fasting blood glucose | mg/dL | 67.8 ± 11.4 | 68.11 ± 11.4 | 0.97 |
| Insulin AUC | — | 43.8 ± 17.0 | 40.5 ± 8.9 | 0.63 |
| Glucose AUC | — | 46,660 ± 10,660 | 43,450 ± 10,328 | 0.57 |
| OC | ng/mL | 109.6 ± 9.7 | 99.5 ± 38.7 | 0.54 |
| RatLAPS | ng/mL | 25.1 ± 2.3 | 21.3 ± 3.8 | 0.05 |
|
| ||||
| Measurements (female) | ||||
| Final body weight | g | 23.1 ± 2.6 | 17.6 ± 2.4 | 0.001 |
| Fasting blood glucose | mg/dL | 52.7 ± 7.6 | 52.6 ± 11.6 | 0.98 |
| Glucose AUC | — | 27,781 ± 3985 | 30,695 ± 5300 | 0.27 |
| OC | ng/mL | 120.7 ± 38.1 | 92.5 ± 35.0 | 0.16 |
| RatLAPS | ng/mL | 25.5 ± 5.1 | 23.8 ± 7.6a | 0.64 |
Abbreviations: AUC: Area under the curve; OC: osteocalcin; RatLAPS; a marker of bone resorption. a n = 8 for this measurement. Significant differences are highlighted in bold font.