Figure 1.

A transmural gradient in the Na/K ATPase current I_P due to AT₁R receptor activation. (A) Representative trace of I_P from a whole-cell patch-clamp recording. Strophanthidin (Str), a specific inhibitor of the Na/K ATPase, was used to block and quantify I_P. (B) Application of 5 μM A2 made I_P the same everywhere at the low ENDO level (lower dashed line), whereas Sar, an inhibitor of the AT₁R, made I_P the same everywhere at its high EPI level (upper dashed line). Significance is denoted by the asterisk (^∗) (P < 0.05).