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. 2014 Jun 3;106(11):2364–2374. doi: 10.1016/j.bpj.2014.04.042

Figure 2.

Figure 2

Possible mechanisms of A2/AT1R regulation of IP. (A) An A2 dose-inhibition curve established by measuring IP from EPI cells incubated in [A2]. Maximum inhibition was 37% and K0.5 was 185 nM. (B) IP was maximally inhibited in all five layers with exogenous A2 and compared to endogenous IP. (C) Percentages of maximum inhibition of IP by endogenous A2 activating AT1Rs in the corresponding layers. (D) Endogenous [A2] was predicted from the inhibitions in panel B based on the dose-inhibition relationship in panel A.