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. 2014 Jun 3;106(11):2364–2374. doi: 10.1016/j.bpj.2014.04.042

Figure 8.

Figure 8

A simplified block diagram for feedback control of contractile force. When load is greater than force, the concentration of A2 in the T-system lumen increases, activating AT1Rs, which initially leads to electrical remodeling. If electrical remodeling is insufficient to restore balance between load and contractile force, then anatomical remodeling eventually occurs.