Figure 5.

Simulation of three-dimensional epithelial morphogenesis in the developing Drosophila egg. (a) Schematic showing the locations of populations of different cell types within the follicular epithelium. (Left panel) Initial locations of the roof cells (blue), floor cells (red), midline cells (orange), and nonspecialized main body cells (gray). (Right panel) Final locations of these cell types relative to the completely formed eggshell. (b) (Clockwise from left) Top and side view of a vertex model simulation of out-of-plane tissue deformation, and final configuration showing a single completely formed appendage. Images reproduced from Osterfield et al. (63).