Table 3.
Not significant (null edge) in FTLD-U with progranulin mutation and in control groups
| |
|
Progranulin (P) |
Control (C) |
|
||
|---|---|---|---|---|---|---|
| Paths | Type | Estimate | P-value | Estimate | P-value | P/C |
| 2911 < -5534 |
Activation |
-0.024 |
0.238 |
0.232 |
0.927 |
OFF/OFF |
| gtp_bind < -2911 |
Activation |
-0.049 |
0.167 |
-0.138 |
0.500 |
OFF/OFF |
| 1742 < -glutam_recp |
Binding/association |
-0.192 |
0.008 |
-0.376 |
0.200 |
ON/OFF |
| 50944 < -9229 |
Binding/association |
0.131 |
0.138 |
0.160 |
0.282 |
OFF/OFF |
| 22941 < -9229 |
Binding/association |
-0.245 |
0.811 |
-0.034 |
0.276 |
OFF/OFF |
| 9456 < -22941 |
Binding/association |
-0.114 |
0.632 |
0.130 |
0.553 |
OFF/OFF |
| 9456 < -50944 |
Binding/association |
0.742 |
0.133 |
0.931 |
0.098 |
OFF/OFF |
| 9455 < -22941 |
Binding/association |
0.142 |
0.224 |
-0.407 |
0.042 |
OFF/ON |
| 9454 < -50944 |
Binding/association |
0.519 |
0.466 |
0.226 |
0.358 |
OFF/OFF |
| 3708 < -9455 |
Binding/association |
-0.322 |
0.067 |
-0.137 |
0.432 |
OFF/OFF |
| 3708 < -9454 |
Binding/association |
0.462 |
0.055 |
0.216 |
0.001 |
OFF/ON |
| 107 < -gtp_bind |
Activation |
0.198 |
0.525 |
0.136 |
0.743 |
OFF/OFF |
| plc_b < -gtp_bind |
Activation |
-0.275 |
0.225 |
-0.234 |
0.127 |
OFF/OFF |
| 5613 < -107 |
Indirect |
-0.012 |
0.000 |
-0.324 |
0.926 |
ON/OFF |
| 1742 < -50944 |
String |
0.971 |
0.013 |
1.166 |
0.062 |
ON/OFF |
| 3708 < -2911 |
String |
-0.068 |
0.054 |
0.143 |
0.501 |
OFF/OFF |
| 9229 < -50944 |
String |
-0.490 |
0.116 |
-1.755 |
0.502 |
OFF/OFF |
| ade_cycl < -5532 |
Directed path |
-0.463 |
0.169 |
0.208 |
0.022 |
OFF/ON |
| ade_cycl < -5534 |
Directed path |
-0.713 |
0.107 |
-0.168 |
0.003 |
OFF/ON |
| glutam_recp < -5532 |
Directed path |
-0.531 |
0.000 |
-1.017 |
0.061 |
ON/OFF |
| 5579 < -9456 |
Directed path |
0.228 |
0.000 |
0.654 |
0.470 |
ON/OFF |
| 5579 < -5534 |
Directed path |
0.295 |
0.000 |
0.986 |
0.388 |
ON/OFF |
| 5613 < -22941 |
Directed path |
-0.581 |
0.741 |
-0.039 |
0.001 |
OFF/ON |
| 22941 < -glutam_recp |
Directed path |
0.044 |
0.000 |
-0.278 |
0.696 |
ON/OFF |
| 3708 < -22941 |
Directed path |
0.264 |
0.000 |
0.443 |
0.072 |
ON/OFF |
| 1742 < -9229 | String | -0.626 | 0.027 | -1.399 | 0.126 | ON/OFF |
glutam_recp = PIRSF ionotropic glutamate receptor; ade_cycl = PIRSF adenylate cyclise; plc_b = PIRSF PLC-beta; gtp_bind = PIRSF GTP-binding regulatory protein Gs alpha chain.