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. 2014 Apr 28;4:6. doi: 10.1186/2045-5380-4-6

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Copyright © 2014 Boehme et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Differential brain activation during the second half of the social vs. neutral video clips. Patients with social anxiety disorder (SAD) displayed enhanced activation within the left and right anterior and mid-insula as compared to healthy control participants (HC; social > neutral video clips). Statistical parametric maps are overlaid on a T1 scan (radiological convention: left = right). The bar graphs show contrasts of parameter estimates (social vs. neutral video clips for first and second half separately; mean ± standard error for maximally activated voxel).