Skip to main content
. 2014 Apr 30;12(5):2408–2421. doi: 10.3390/md12052408

Table 3.

The effects of APS12-2 and APS3 on significant parameters in rats.

Measured Parameters APS12-2 * APS3 **
LD50 (mice) 11.5 mg/kg 7.25 mg/kg
ECG (rats)

  • bradycardia

  • second degree atrioventricular block

  • Ventricular extrasystoles

  • Transient tachycardia
Arterial blood pressure Steep decrease immediately after application First a decrease, then an increase above base-line value
Breathing Respiratory arrest soon after application No effect
Biochemical parameters Statistically significant increase in K+ level (10.44 ± 0.44 mM) Statistically significant increase in K+ level (5.66 ± 0.37 mM)
Muscle contraction No effect up to 8.6 mg/kg ID50 = 37.25 mg/kg

LD50, half-lethal dose; ID50, median inhibitory dose; ECG, electrocardiography; * [8]; ** [42].