Table 4.
BACE1 inhibitors.
| Compound/organism | IC50 (μM) |
|---|---|
| Xestosaprol D/sponge Xestospongia sp. | 93.2 [72] |
| Xestosaprol F/sponge Xestospongia sp. | 135.0 [69] |
| Xestosaprol G/sponge Xestospongia sp. | 155.0 [69] |
| Xestosaprol H/sponge Xestospongia sp. | 82.0 [69] |
| Xestosaprol I/sponge Xestospongia sp. | 163.0 [69] |
| Xestosaprol J/sponge Xestospongia sp. | 90.0 [69] |
| Xestosaprol K/sponge Xestospongia sp. | 93.0 [69] |
| Xestosaprol L/sponge Xestospongia sp. | 98.0 [69] |
| Xestosaprol M/sponge Xestospongia sp. | 104.0 [69] |
| Dictyodendrin F/sponge Ianthella sp. | 1.5 [74] |
| Dictyodendrin H/sponge Ianthella sp. | 1.0 [74] |
| Dictyodendrin I/sponge Ianthella sp. | 2.0 [74] |
| Dictyodendrin J/sponge Ianthella sp. | 2.0 [74] |
| Dictazole A/sponge Smenospongia cerebriformis Duchassaing and Michelotti | 135.0 [71] |
| Topsentinol K trisulfate/sponge Topsentia sp. | 1.2 [70] |
| Lamellarin O/sponge Ianthella sp. | 40% (at 10 μM) [73] |
| Lamellarin O1/sponge Ianthella sp. | 60% (at 10 μM) [73] |
| Lamellarin O2/sponge Ianthella sp. | 40% (at 10 μM) [73] |
| Ianthellidone F/sponge Ianthella sp. | 40% (at 10 μM) [73] |