Table 12.
Compounds with their total synthesis described.
| Compound | Class of compounds | Pharmacologic activity | Ref. |
|---|---|---|---|
| Lembehyne | Linear polyacetylene | Neuritogenic agent | [207] |
| Turbotoxin A | Diiodotyramine derivative | AChE inhibitor | [67] |
| Lamellarin O | Alkaloid | BACE1 inhibitor | [208] |
| Hymenialdisine and analogs | Diterpene isocyanide | Kinase inhibitor | [209,210,211,212] |
| Lamellarin D and analogs | Alkaloid | Kinase inhibitor | [213,214,215,216] |
| Lamellarin H | Alkaloid | Kinase inhibitor | [213] |
| Lamellarin L | Alkaloid | Kinase inhibitor | [215,217] |
| Lamellarin N | Alkaloid | Kinase inhibitor | [215] |
| Leucettamine B and analogs | Alkaloid | Kinase inhibitor | [90,218] |
| Manzamine A | Alkaloid | Kinase inhibitor | [219,220] |
| Palinurin | Furanoterpenoid | Kinase inhibitor | [221] |
| Fascaplysin | Alkaloid | Kinase inhibitor | [222,223] |
| ω-SO-3 | ω-Conotoxin | Calcium channels modulator | [224] |
| δ-SVIE | δ-Conotoxin | Sodium channels modulator | [122] |
| μ-PIIIA | μ-Conotoxin | Sodium channels modulator | [116] |
| κM-RIIIK | κM-Conotoxin | Potassium channels modulator | [128] |
| Anabaseine | Alkaloid | AChR modulator | [225] |
| (−)-Pictamine | Alkaloid | AChR modulator | [226,227] |
| (−)-Lepadin B | Alkaloid | AChR modulator | [228,229,230] |
| α-Qc1.2 | α-Conotoxin | AChR modulator | [139] |
| α-ImI | α-Conotoxin | AChR modulator | [138,231] |
| α-ImII | α-Conotoxin | AChR modulator | [138] |
| Spirolide C | Macrocyclic imine | AChR modulator | [232] |
| Gymnodimine | Macrocyclic imine | AChR modulator | [233] |
| Neodysiherbaine | Amino acid | Glu receptor modulator | [234,235,236,237] |
| Daminin | Alkaloid | Glu receptor modulator | [152] |
| Kainic acid | Amino acid | Glu receptor modulator | [238,239,240,241] |
| Domoic acid | Amino acid | Glu receptor modulator | [242] |
| Conatokin-L | Conantokin | Glu receptor modulator | [153,243] |
| Conatokin-R | Conantokin | Glu receptor modulator | [157] |
| Aureol | Sesquiterpene | 5-HT receptor modulator | [244,245,246] |
| N,N-Dimethyltryptamine | Alkaloid | 5-HT receptor modulator | [247] |
| Barettin | Brominated cyclodipeptide | 5-HT receptor modulator | [248] |
| Damipipecolin | Bromopyrrole alkaloid | 5-HT receptor modulator | [249] |
| Damituricin | Bromopyrrole alkaloid | 5-HT receptor modulator | [249] |
| Aplysamine-1 and analogs | Bromotyrosine derived metabolite | histamine receptor modulator | [160,250] |
| Aplysinopsin and analogs | Indole alkaloid | Glycine receptor modulator | [251] |
| χ-MrIA | χ-Conotoxin | Norepinephrine transporter modulator | [166] |
| Astaxanthin | Carotenoid | Neuroprotection against 6-OHDA or MPP+ treatments | [252] |
| Nanolobatolide | C18-terpene | Anti-neuroinflammatory activity | [253] |
| Δ9(12)-Capnellene-8β,10α-diol | Sesquiterpene | Anti-neuroinflammatory activity | [254,255] |
| (−)-8,15-Diisocyano-11(20)-amphilectene | Diterpene isocyanide | Anti-neuroinflammatory activity | [256] |
| Monamphilectine A | Diterpene isocyanide | Anti-neuroinflammatory activity | [257] |
| Pseudopterosin | Diterpene | Anti-neuroinflammatory activity | [258,259,260,261] |
| Eusynstyelamide A | Brominated tryptophan-derivative | Anti-neuroinflammatory activity | [262] |