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. 2014 Jun 11;5:140. doi: 10.3389/fphar.2014.00140

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Copyright © 2014 Lee, Perry, Heywood, Reese, Bonner, Hatfield, Silver, Visconti, Hoffman and Tourkina.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathology of skin lesions in SSc patients. Skin sections from Control subjects and SSc patients were stained with H&E or Masson's Trichrome (MT). 100 μm bars are present in each low-magnification panel (top two rows). High-magnification MT images with 50 μm bars (third row) expand on the boxed regions in the low-magnification MT images. Note that collagen fibrils are packed more densely in SSc skin than in Control skin. Similar results were observed in four subjects in each category.