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. 2014 Jun 11;5:140. doi: 10.3389/fphar.2014.00140

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Copyright © 2014 Lee, Perry, Heywood, Reese, Bonner, Hatfield, Silver, Visconti, Hoffman and Tourkina.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bone marrow cells from bleomycin-treated mice are hypermigratory toward CCR5 ligands and this migration is blocked by CSD. Migration experiments were performed as described in the Methods using bone marrow cells from mice treated with bleomycin or saline vehicle. Mice were treated with CSD as indicated. Lower wells contained 100 ng/ml of MIP1α or MIP1β. Cells that had migrated were counted in six high power fields per filter. Note for both MIP1α and MIP1β, that the induction of migration was extremely enhanced in bone marrow cells from bleomycin-treated mice compared to bone marrow cells from vehicle-treated mice and that CSD completely blocked the enhanced migration. The data represent the average ± s.e.m. from three independent experiments using cells from different subjects.