Figure 8. Lipocalin2 is required for efficient wound healing.

(a) Images of skin wound sites taken immediately after wounding and 11 days post wounding. After full-thickness wounds of 1cm² were created on the dorsal skins of nude mice, anti-Lcn2 (n=8) or isotype control (n=6) antibodies were applied topically onto the wound sites every other day. Surface areas of the wounds were measured at the initial time point and 11 days post wounding.

(b) Graph quantifying the surface areas of the wounds as a percentage of the original wounds 11 days post wounding, anti-Lcn2 (n=8) or isotype control (n=6). Data are mean ± s.d. *p<0.05 (Student’s t-test).

(c) Images of skin wound sites taken immediately after wounding and 10 days post wounding of WT and Lcn2 KO mice. 1cm² were created on the dorsal skins of WT and Lcn2 KO mice (n=7). Surface areas of the wounds were measured at the initial time point and 10 days post wounding.

(d) Graph quantifying the surface areas of the wounds as a percentage of the original wounds 10 days post wounding, WT (n=7) and Lcn2 KO mice (n=7). Data are mean ± s.d. **p<0.001 (Student’s t-test).