Figure 6. Access of K_V’s inactivation gate.

(a) Cartoon of the proposed inactivation gating mechanism. (b) Model of a K_V channel based on the ‘paddle-chimaera channel’ structure30. For clarity, the membrane region of the channel contains only two opposite selectivity filters and S6 transmembrane segments with their equivalent positions I470 in cyan. Similarly, two opposite T1 domains and their linkers are shown at the cytoplasmic region of the channel with equivalent positions E192 and D193 shown in blue.