Table 2.

Intervention Compared With Usual Care Differences in Primary Clinical Outcomes

PRIMARY OUTCOMES	Total N of Patients	CONTINUOUS OUTCOMES			p-Value
		Mean (SD)		Average Differences between groups Intervention – UC) Mean (95% CI)
		Intervention	Usual Care
Decrease in depression score (SCL-20) from Baseline:					*<0.001
6 Month	183	0.72 (0.77)	0.69 (0.76)	0.03 (−0.25 to 0.19)	0.779
12 Month	181	1.10 (0.74)	0.62 (0.78)	0.48 (−0.70 to –0.25)	< 0.001
18 Month	170	1.06 (0.74)	0.70 (0.81)	0.36 (−0.60 to –0.12)	0.004
Decrease in functional impairment score (SDS) from Baseline:					*<0.050
6 Month	183	1.58 (3.28)	2.14 (2.60)	−0.56 (−0.30 to 1.43)	0.200
12 Month	180	2.56 (3.10)	1.95 (2.67)	0.62 (−1.46 to 0.23)	0.154
18 Month	169	2.56 (3.25)	2.08 (3.36)	0.47 (−1.48 to 0.42)	0.354

SD = standard deviation;SCL-20, Hopkins Symptom Checklist-20, range 0–422: SDS, Sheehan Disability Scale (SDS), range 0 – 10.23

^*Group-by-time interaction: baseline to 18 months.