Table 4.
Association of HDL particle subclasses with incident CHD in participants with apolipoprotein B ≥ 90mg/dL (N=17 227, CHD events =838)
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | P-Trend | *Per 1 SD | P | |
|---|---|---|---|---|---|---|---|
| Total HDL-P (7.4–13.5 nm) | |||||||
| Range, μmol/L | ≤ 31.39 | 31.40–34.66 | 34.67–38.25 | ≥38.26 | |||
| Model 1, HR (95% CI) | 1 | 0.84 (0.68–1.04) | 0.76 (0.61–0.94) | 0.73 (0.60–0.89) | 0.003 | 0.90 (0.85–0.96) | 0.0007 |
| Model 2, HR (95% CI) | 1 | 0.85 (0.68–1.05) | 0.72 (0.58–0.89) | 0.65 (0.53–0.80) | <0.0001 | 0.86 (0.81–0.92) | <0.0001 |
|
| |||||||
| Very large (10.3–13.5 nm) | |||||||
| Range, μmol/L | ≤ 1.53 | 1.54–2.69 | 2.70–4.32 | ≥4.33 | |||
| Model 1, HR (95% CI) | 1 | 0.84 (0.71–1.01) | 0.67 (0.55–0.81) | 0.62 (0.50–0.77) | <0.0001 | 0.82 (0.77–0.88) | <0.0001 |
| Model 2, HR (95% CI) | 1 | 0.93 (0.78–1.12) | 0.84 (0.68–1.04) | 1.08 (0.85–1.38) | 0.70 | 0.96 (0.88–1.04) | 0.26 |
|
| |||||||
| Large (8.6–10.2 nm) | |||||||
| Range, μmol/L | ≤ 3.51 | 3.52–4.92 | 4.93–6.55 | ≥6.56 | |||
| Model 1, HR (95% CI) | 1 | 0.71 (0.59–0.86) | 0.71 (0.59–0.86) | 0.54 (0.44–0.65) | <0.0001 | 0.82 (0.77–0.87) | <0.0001 |
| Model 2, HR (95% CI) | 1 | 0.75 (0.62–0.91) | 0.80 (0.66–0.98) | 0.65 (0.52–0.80) | 0.0003 | 0.87 (0.82–0.93) | <0.0001 |
|
| |||||||
| Medium (8.3–8.5 nm) | |||||||
| Range, μmol/L | ≤ 5.52 | 5.53–8.02 | 8.03–10.80 | ≥10.81 | |||
| Model 1, HR (95% CI) | 1 | 0.82 (0.68–1.00) | 0.69 (0.56–0.84) | 0.69 (0.58–0.84) | 0.0001 | 0.89 (0.83–0.95) | 0.0002 |
| Model 2, HR (95% CI) | 1 | 0.93 (0.76–1.14) | 0.82 (0.66–1.02) | 0.80 (0.64–1.00) | 0.04 | 0.93 (0.86–1.00) | 0.04 |
|
| |||||||
| Small (8.0–8.2 nm) | |||||||
| Range, μmol/L | ≤ 4.12 | 4.13–6.33 | 6.33–9.17 | ≥9.18 | |||
| Model 1, HR (95% CI) | 1 | 1.16 (0.94–1.43) | 1.09 (0.88–1.35) | 1.14 (0.94–1.39) | 0.35 | 1.04 (0.98–1.11) | 0.20 |
| Model 2, HR (95% CI) | 1 | 1.08 (0.87–1.33) | 0.94 (0.76–1.17) | 0.81 (0.65–1.01) | 0.01 | 0.91 (0.85–0.98) | 0.01 |
|
| |||||||
| Very small (7.4–7.9 nm) | |||||||
| Range, μmol/L | ≤ 8.30 | 8.31–11 | 11.01–13.69 | ≥13.70 | |||
| Model 1, HR (95% CI) | 1 | 1.24 (0.98–1.57) | 1.45 (1.16–1.82) | 1.52 (1.23–1.89) | <0.0001 | 1.16 (1.08–1.24) | <0.0001 |
| Model 2, HR (95% CI) | 1 | 1.17 (0.91–1.49) | 1.14 (0.90–1.46) | 0.93 (0.72–1.20) | 0.22 | 0.94 (0.87–1.02) | 0.16 |
HDL-P, HDL particle concentration; nm, nanometer; HR, hazard ratio; CI, confidence interval.
Natural log transformation was used to compute values for very large and large HDL subclasses.
Model 1 included age, race/ethnicity, blood pressure, smoking, postmenopausal status, hormone replacement therapy, and treatment assignment.
Model 2 included model 1 covariables plus body mass index, diabetes, LDL cholesterol and particle concentration, triglycerides, and the other 4 HDL subclasses Due to participants with missing information on adjusted covariates, Model 1 included a total of 16 800 participants (817 events) and Model 2 included a total of 16 459 participants (786 events)