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. Author manuscript; available in PMC: 2014 Jun 11.
Published in final edited form as: Anticancer Agents Med Chem. 2013 May;13(4):595–602. doi: 10.2174/1871520611313040009

Figure 4. INT2-31 decreases phosphorylation of Y13454 on cMET.

Figure 4

Following 24 hours of serum starvation, and 10 min HGF treatment of Panc-1 cells in the presence of increasing doses of INT2-31, phosphorylation of Y1345 on cMETis reduced in a dose dependent manner, whereas Y1230-34-35 remained unchanged. These results indicate that cMET was induced by HGF, yet disruption of its binding to FAK suppressed its full activation.