Table 2.
Oncogenes and oncogenic pathway targets of miR-1 in cancers.
Gene name | Genbank accession number | Chromosome location | Functions | Reference number |
---|---|---|---|---|
Met | NM_000245.2 | 7q31 | Proto-oncogenic receptor tyrosine kinase | [42, 44, 68] |
HDAC4 | NM_006037.3 | 2q37.3 | Histone deacetylase activity; represses transcription | [14, 31, 39] |
Pim-1 | NM_002648.3 | 6p21.2 | Proto-oncogene | [33] |
FOXP1 | NM_001244810.1 | 3p14.1 | Regulate gene transcription; tumor suppressor | [33, 39] |
TAGLN2 | NM_003564.1 | 1q21-q25 | Earliest marker of differentiated smooth muscle | [50, 56, 64] |
PNP | NM_000270.3 | 14q13.1 | Purine metabolism | [50, 58] |
PTMA | NM_002823.4 | 2q37.1 | Enhance cell-mediated immunity | [58] |
CXCR4 | NM_001008540.1 | 2q21 | Chemokine receptor | [65] |
CCND2 | NM_001759.3 | 12p13 | Regulator of cyclin-dependent kinase | [65, 71] |
SRSF9 | NM_003769.2 | 12q24.31 | [57] | |
FN1 | NM_212482.1 | 2q34 | Involved in cell adhesion, growth, and migration | [61] |
ETS1 | NM_001143820.1 | 11q23.3 | Proto-oncogene | [40] |
Endothelin 1 | NM_001955.4 | 6p24.1 | Involved in vascular disorders | [41] |
Slug | NM_003068.4 | 8q11 | Transcriptional repressor and has antiapoptotic activity | [38] |
CXCL12 | NM_199168.3 | 10q11.1 | Chemotactic for lymphocytes | [65] |