Table 2.

Biodistribution data (%ID/g) of ^99mTc-NGR in HepG2 hepatoma tumor-bearing nude mice at 1, 4, 8, and 12 h postinjection (n = 5, mean ± SD).

	1 h	4 h	8 h	12 h	Blocking (1 h)
Blood	3.82 ± 0.41	1.75 ± 0.39	0.98 ± 0.22	0.75 ± 0.31	2.56 ± 0.34
Heart	3.74 ± 0.54	2.26 ± 0.33	1.15 ± 0.32	1.07 ± 0.25	2.73 ± 0.29
Lung	2.52 ± 0.83	2.13 ± 0.44	1.86 ± 0.38	1.21 ± 0.31	2.04 ± 0.28
Liver	4.07 ± 0.76	3.85 ± 0.73	3.44 ± 0.52	3.26 ± 0.47	3.27 ± 0.16
Kidney	7.93 ± 2.13	7.03 ± 0.95	6.21 ± 0.43	5.96 ± 0.41	5.03 ± 0.97
Spleen	2.37 ± 0.43	2.09 ± 0.60	1.88 ± 0.42	1.72 ± 0.37	1.89 ± 0.22
Stomach	3.07 ± 0.56	2.20 ± 0.26	1.61 ± 0.39	1.56 ± 0.32	3.41 ± 0.31
Intestine	2.65 ± 1.06	2.18 ± 0.96	1.93 ± 0.22	1.60 ± 0.27	2.40 ± 0.59
Muscle	0.53 ± 0.33	0.46 ± 0.11	0.43 ± 0.14	0.39 ± 0.22	0.48 ± 0.27
Tumor	2.52 ± 0.83	3.03 ± 0.71	3.26 ± 0.63	2.81 ± 0.25	1.65 ± 0.61
Tumor-to-normal tissue uptake ratio at 1 h postinjection
			T/M	4.75 ± 0.91
			T/L	0.62 ± 0.33
			T/K	0.32 ± 0.15