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. 2014 May 28;2:694–701. doi: 10.1016/j.redox.2014.05.005

Fig. 1.

Fig. 1

(A) Effects of specific inhibitors targeting the main free radical-generating enzymes and protein kinase C (PKC)-a, PKC-ß and PKC-ßII isoforms on O2•- production (n = 3) in human brain microvascular endothelial cells (HBMEC) subjected to hyperglycaemia (HG; 25 mM d-glucose) for 72 h. Effects of inhibitors for PKC-a, PKC-ß and PKC-ßII on gp91-phox(n = 3) (B) and p22-phox (n = 3) (C) protein expressions in HBMEC exposed to HG. Data are expressed as mean ± SEM. *P < 0.05 versus normoglycaemia (NG), +P < 0.05 versus HG.