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Effect of protein kinase C-ßI (PKC-ßI) gene silencing on TUNEL staining (Bar, 100 µm) (A), DNA fragmentation rates (n = 3) (B), caspase-3/7 activities (n = 6) (C) and Bax protein expression (n = 3) (D) in human brain microvascular endothelial cells exposed to PMA (100 nM) for 4 h. Data are expressed as mean ± SEM. *P < 0.05 versus normoglycaemia (NG), +P < 0.05 versus PMA.
