Figure 1.

Foxp3⁺ Treg accumulate at sites of Leishmania infection. TCR^−/− mice were injected with CD4⁺CD25⁻ T cells from cyan fluorescent protein-expressing transgenic mice and CD4⁺Foxp3⁺ Treg from Foxp3-GFP-knock-in mice. Leishmania expressing red fluorescent protein were injected intra-dermally into the ear. This image was taken at 1 month post-infection (red: Leishmania; cyan: CD4⁺CD25⁻ T cells; green: CD4⁺Foxp3⁺ Treg). dysregulation of Treg function requires further analysis.