Table 2.

Type and Number of First and Second Degree Family Members of Cases (n=519) and Controls (n=1015)

Relatives with respect to proband	Cases Total Relatives (n= 15163)		Controls Total Relatives (n= 30884)		Total Relatives (n= 46047)
	N	%	N	%	N	%
All First Degree	3768	100d	7905	100d	11673	100d
Brother	826	21.9	1730	21.9	2556	21.9
Sistera	807	21.4	1575	19.9	2382	20.4
Sibling Sex Unknown	0	0.0	0	0.0	0	0.0
Son	574	15.2	1338	16.9	1912	16.4
Daughter	529	14.0	1250	15.8	1779	15.2
Child Sex Unknown	0	0.0	0	0.0	0	0.0
Fathersb	512	13.6	1002	12.7	1514	13.0
Mothersc	520	13.8	1010	12.8	1530	13.1
All Second Degree	11395	100e	22979	100e	34374	100e
Maternal Grandfather	438	3.8	870	3.8	1308	3.8
Maternal Grandmother	460	4.0	911	4.0	1371	4.0
Paternal Grandfather	380	3.3	792	3.5	1172	3.4
Paternal Grandmother	397	3.5	814	3.5	1211	3.5
Male Grandchildren	638	5.6	1438	6.3	2076	6.0
Female Grandchildren	657	5.8	1419	6.2	2076	6.0
Grandchildren Sex Unknown	0	0.0	0	0.0	0	0.0
Maternal Uncle	1134	10.0	2219	9.7	3353	9.8
Maternal Aunt	1036	9.1	2136	9.3	3172	3172
Maternal Aunt/Uncle Sex Unknown	72	0.6	55	0.2	127	0.4
Paternal Uncle	1006	8.8	2104	9.2	3110	9.1
Paternal Aunt	1052	9.2	1947	8.5	2999	8.7
Paternal Aunt/Uncle Sex Unknown	41	0.4	77	0.3	118	0.3
Maternal Half-brother	40	0.4	72	0.3	112	0.3
Maternal Half-sister	44	0.4	63	0.3	107	0.3
Maternal Half-siblings Sex Unknown	0	0.0	1	0.0	1	0.0
Paternal Half-brother	24	0.2	42	0.2	66	0.2
Paternal Half-sister	28	0.3	48	0.2	76	0.2
Paternal Half-siblings Sex Unknown	0	0.0	4	0.0	4	0.0
Nephew	2004	17.6	4059	17.7	6063	17.6
Niece	1876	16.5	3866	16.8	5742	16.7
Niece/Nephew Sex Unknown	68	0.6	42	0.2	110	0.3

^aCase (n=2) or control (n=2) identical twin siblings excluded.

^bIdentical twins of father for cases (n=2) and control (n=2) included.

^cIdentical twins of mother for cases (n=2) control (n=1) included.

^d% of all first degree

^e% of all second degree