Table 2.
Behavioral and neurochemical effects of persistent NRG1 and EGF overexpression from their transgenes.
| NRG-1 TG | EGF-TG | ||
|---|---|---|---|
| Behaviors | Sound startle | No change | No change |
| Fear-learning | INCREASE | Modest decrease | |
| Locomotor | INCREASE | No change | |
| PPI | Modest decrease | DECREASE | |
| Social behaviors | DECREASE | DECREASE | |
|
| |||
| GABA | GAD 65/67 | No change | No change |
| PV | INCREASE (cortex) | No change | |
|
| |||
| Glutamate | NR1 (GluN1) | No change | No change* |
| NR2 (GluN2) | No change | No change* | |
| GluR1 (GluA1) | No change | No change* | |
|
| |||
| Dopamine | TH | DECREASE (cortex) | DECREASE (striatum) |
| DAT | No change | No change | |
| DA | DECREASE (hippocampus) | INCREASE (accumbens) | |
| DOPAC | DECREASE (hippocampus) | INCREASE (accumbens) | |
*represent effects on basal ganglia regions GAD: glutamate decarboxylase; PV: parvalbumin; TH: tyrosine hydroxylase; DA: dopamine; DAT: dopamine transporter; DOPAC: 3,4-dihydroxy-phenylacetic acid. Statistical significance represents P < 0.05 and “modest” indicates marginal changes with 0.05 < P < 0.10.