Fig. 3.

Stereo view of intermolecular contacts between one TRD loop of Dnmt1 and the DNA major groove in the productive covalent Dnmt1-DNA complex. The 5-methyl group from the 5mC in the parental strand is coloured in green. The flipped-out target cytosine is in purple, the flipped-out cytosine in the parental strand is in dark blue, and the guanine two bases downstream of the target cytosine is in light blue. Amino acid residues that are in contact with DNA are labelled.