Figure 2.

The effect of unilateral biochemical manipulations. The specified manipulations were placed on the side that induced rotation in the right direction (marked with an arrow). The direction of rotation was always contralateral to the striatum with a high DA concentration (left). (I) systemic administration of d-amphetamine (enhances natural asymmetry). (II) 6-OHDA lesion of the striatum. (III) DA agonists, Acetylcholine antagonists or NMDA administered to the striatum. (IV) 6-OHDA lesion of the MFB. (V) 6-OHDA lesion or DA administration to the SNc. (VI) GABA antagonists administered to the SNr. (VII) DA agonists, Acetylcholine agonists or GABA agonists administered to the SNr.