Table 3.

Genetic models of schizophrenia

Gene/ Protein/ Function	Animal models	Behavioral alterations	Cerebellar pathology	Strengths	Caveats	Refs
G72/G30 Chr. 13q LG72 protein DAO regulator mitochondrial protein	G72Tg mice	Impaired PPI reversible with haloperidol Increased sensitivity to PCP Motor-coordination deficits Increased compulsive behaviors Deficits in smell identification	Not reported	Expression of primate-specific mutation with high expression in the cerebellum	Constitutive over-expression	Otte et al., 2009, 2011; Filiou et al., 2012
22q11.2 deletion encompasses 27 genes	Df(16)A+/− mice	Hyperactive and anxiety Impaired contextual fear-conditioning	Abnormalities within the deep nuclei and the cortex	Deletion of the segment synthenic to the human chromosome segment	No region- or time-dependent expression	Stark et al., 2008; Ellegood et al., 2013
DISCI Scaffold protein with extended interactome	Inducible expression of mutant DISC1	Elevated ambulatory and rearing activity; Deficits in object recognition and social recognition Decreased fear conditioning	Decreased volumes of the cerebellum and PC	Region-specific and time-dependent expression DOX-regulated	Over-expression of heterologous protein	Shevelkin et al., Manuscript in preparation