Table 3.

Summary of the effects of intra-mPFC R-CPP in combinations with 5-HT_1A, 5-HT_2A, and 5-HT_2C agents, an mGlu_2/3 agonist and various antipsychotics on attention and executive control and glutamate (GLU) and serotonin (5-HT) release in the mPFC.

	Attention	Impulsivity	Compulsivity	GLU	5-HT
R-CPPa,b	↓	↑	↑	↑	↑
SEROTONIN AGENTS
+ 8-OH-DPATc,d	0	↑	0	0	0
+ M100907a,c,d	0	0	↑	0	0
+ Ro60-0175e	0	0	↑	0	0
mGlu2/3 AGENTS
+ LY379268f	0	0	↑	0	nd
ANTIPSYCHOTICS
+ haloperidolg,h	↓	0	0	↑	0
+ aripiprazoleh	0	↑	0	0	0
+ olanzapineh	0	0	↑	0	0
+ clozapinei	0	0	↑	0	0
+ sertindolei (0.32 mg/kg)	0	↑	↑	0	0
+ sertindolei (2.5 mg/kg)	↓	↑	↑	↑	↑

Data from:

^aMirjana et al., 2004,

^bCeglia et al., 2004,

^cCarli et al., 2006a,

^dCalcagno et al., 2006,

^eCalcagno et al., 2009,

^fPozzi et al., 2011,

^gBaviera et al., 2008,

^hCarli et al., 2011b,

ⁱCarli et al., 2011a.

↓, decrease; ↑, increase; 0, reversal of R-CPP-induced effect.