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Cytokine mRNA expression levels in lung. Groups of animals were immunized intranasally three times with PBS, CTB, rFim2, or CTB-Fim2 every 12 days followed by intranasal challenge with 5 × 107 UFC of the Tohama I strain of B. pertussis. At 8 days postinfection, animals were killed and lung samples were collected for measuring mRNA levels of IFN-γ (a) and IL-4 (b). Statistical differences were observed between CTB-Fim2 and all other groups except rFim2 (P < 0.001).
