Table 2.
Agreement (%) between academic readers and Veridex consensus (VC)
| |
No CTC versus CTC |
|
|
CTC HER2- versus CTC HER2+ |
|
|||
|---|---|---|---|---|---|---|---|---|
| RDs | N | Agreement (%) | Kappa statistic | Kappa agreement | N | Agreement (%) | Kappa statistic | Kappa agreement |
| A |
267 |
91.8% |
0.83 |
Almost perfect |
155 |
81.3% |
0.63 |
Substantial |
| B |
267 |
91.4% |
0.82 |
Almost perfect |
155 |
81.3% |
0.63 |
Substantial |
| C |
267 |
92.5% |
0.84 |
Almost perfect |
155 |
90.3% |
0.81 |
Almost perfect |
| D |
267 |
91.8% |
0.83 |
Almost perfect |
155 |
71.6% |
0.47 |
Moderate |
| E |
266 |
95.1% |
0.90 |
Almost perfect |
154 |
93.5% |
0.87 |
Almost perfect |
| F |
267 |
92.1% |
0.84 |
Almost perfect |
155 |
87.1% |
0.75 |
Substantial |
| G |
267 |
91.4% |
0.82 |
Almost perfect |
155 |
91.0% |
0.82 |
Almost perfect |
| H |
267 |
91.4% |
0.82 |
Almost perfect |
155 |
88.4% |
0.78 |
Substantial |
| I |
267 |
92.1% |
0.84 |
Almost perfect |
155 |
91.6% |
0.84 |
Almost perfect |
| J |
267 |
83.9% |
0.65 |
Substantial |
155 |
76.8% |
0.55 |
Moderate |
| K |
220 |
87.3% |
0.74 |
Substantial |
117 |
79.5% |
0.59 |
Moderate |
| L |
266 |
92.9% |
0.85 |
Almost perfect |
154 |
94.8% |
0.90 |
Almost perfect |
| M |
220 |
87.3% |
0.74 |
Substantial |
117 |
90.6% |
0.82 |
Almost perfect |
| N |
267 |
95.9% |
0.92 |
Almost perfect |
155 |
92.3% |
0.85 |
Almost perfect |
| O |
267 |
96.6% |
0.93 |
Almost perfect |
155 |
92.9% |
0.86 |
Almost perfect |
| P |
267 |
94.4% |
0.88 |
Almost perfect |
155 |
85.2% |
0.72 |
Substantial |
| Q |
218 |
91.7% |
0.83 |
Almost perfect |
113 |
84.1% |
0.69 |
Substantial |
| R |
218 |
91.7% |
0.83 |
Almost perfect |
113 |
85.8% |
0.73 |
Substantial |
| S |
220 |
92.7% |
0.85 |
Almost perfect |
117 |
86.3% |
0.73 |
Substantial |
| T |
266 |
69.2% |
0.37 |
Fair |
154 |
51.3% |
0.25 |
Fair |
| U |
267 |
91.4% |
0.82 |
Almost perfect |
155 |
91.0% |
0.82 |
Almost perfect |
| V | 220 | 91.8% | 0.84 | Almost perfect | 117 | 82.1% | 0.66 | Substantial |
CTC, circulating tumor cell; RDs, readers; N, number of images. Kappa Agreement, below 0.00 Poor; 0.00 to 0.20 Slight; 0.21 to 0.40 Fair; 0.41 to 0.60 Moderate; 0.61 to 0.80 Substantial; 0.81 to 1.00 Almost Perfect.