Skip to main content
. Author manuscript; available in PMC: 2015 May 7.
Published in final edited form as: Neuron. 2014 May 7;82(3):645–658. doi: 10.1016/j.neuron.2014.03.028

Fig. 3. FMRP in the adult nucleus accumbens is required for normal behavioral sensitization to cocaine.

Fig. 3

(A) Example intra-NAc stereotaxic injection with respect to the mouse brain atlas (Bregma 0.98 mm) (Paxinos and Franklin, 2001). (B) Timeline for viral stereotaxic surgery and testing. (C) Loss of NAc FMRP does not recapitulate the reduction in CPP observed in total Fmr1 KO mice (7.5 mg/kg; n=18 CRE, 22 GFP). (D) Floxed-Fmr1 conditional KO mice injected with AAV-CRE-GFP show a significant deficit in COC sensitization (15 mg/kg) compared to those injected with AAV-GFP, which is not significant at acute exposure (n=18 CRE, 22 GFP). Cumulative beam breaks for the first 20 min of each daily trial following injection are shown. (LV=lateral ventricle, aca=anterior commissure; ns=not significant; * p<0.05; data shown are mean±S.E.M.; see also Table S1 & Fig. S3.)