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. 2003 Feb;64(2):96–115. doi: 10.1016/S0011-393X(03)00018-3

Table II.

Pharmacokinetic parameters for pentoxifylline (PTX) and 1-(5′-hydroxyhexyl)-3,7-dimethylxanthine (M-1) in pediatric patients (current study) compared with adults.12–14

Study Dose Tmax, h Cmax, ng/mL t1/2, h AUC0–∞, ng/mL·h Clearance, L/kg·h Volume, L/kg
PTX
 Smith et al,12 mean 400 mg PO 0.29 1607 0.84 1229 – –
 Rames et al,13 mean 100 mg IV – – 0.83 – 3.62 4.15
 Current study, range 10–25 mg/kg PO daily 0.3–2.0 83–8270 0.2–3.5 213–15,922 0.5–23.5 0.6–16.9


M-1
 Smith et al,12 mean 400 mg PO 0.83 2000 0.96 5101 – –
 Beermann et al,14 mean 400 mg PO 1.80 1937 0.90 5031 – –
 Current study, range 10–25 mg/kg PO daily 0.3–3.0 192–3391 0.4–3.4 279–13,235 – –

Tmax = time to Cmax; Cmax = maximum plasma concentration; t1/2 = half-life; AUC0–∞ = area under the plasma concentration–time curve from time 0 to infinity.