Table II.
Clinical and biochemical values in study patients. (Data are expressed as mean [SE].)∗
| Parameter | Normal Value | Baseline | 8 Weeks | 16 Weeks |
|---|---|---|---|---|
| BMI, kg/m2 | <25 | |||
| Group A | 25.1 (0.9) | 25.2 (1.0) | 25.1 (1.1) | |
| Group B | 25.2 (1.0) | 24.3 (0.6) | 23.9 (0.6) | |
| SBP, mm Hg | ≤140 | |||
| Group A | 137 (4) | 136 (3) | 134 (4) | |
| Group B | 138 (2) | 135 (3) | 140 (4) | |
| DBP, mm Hg | ≤90 | |||
| Group A | 82 (3) | 81 (3) | 79 (2) | |
| Group B | 80 (1) | 79 (1) | 81 (2) | |
| FPG, mg/dL | <126 | |||
| Group A | 107 (10) | 102 (7) | 118 (15) | |
| Group B | 131 (12) | 128 (11) | 122 (13) | |
| HbA1c, % | 4–7 | |||
| Group A | 5.7 (0.2) | 6.1 (0.4) | 5.4 (0.3) | |
| Group B | 6.3 (0.5) | 6.1 (0.4) | 6.2 (0.5) | |
| Fasting insulin, μU/mL | 3.1–16.9 | |||
| Group A | 11.2 (1.9) | 11.3 (1.9) | 13.5 (2.7) | |
| Group B | 10.8 (1.4) | 11.1 (1.2) | 11.2 (1.2) | |
| FFA, mEq/L | 0.14–0.85 | |||
| Group A | 0.70 (0.11) | 0.56 (0.16) | 0.58 (0.13) | |
| Group B | 0.71 (0.11) | 0.57 (0.04) | 0.76 (0.29) | |
| Serum uric acid, mg/dL | 3.0–7.0 | |||
| Group A | 7.8 (0.2) | 5.9 (0.3)† | 7.6 (0.2) | |
| Group B | 8.1 (0.2) | 6.9 (0.5)‡ | 5.7 (0.3)§‖ | |
| FEUA, % | ≤5 | |||
| Group A | 6.6 (0.5) | 9.5 (1.4)¶ | 6.5 (0.6) | |
| Group B | 5.4 (0.5) | 7.8 (1.0)¶ | 10.6 (1.0)¶# | |
| Serum creatinine, mg/dL | 0.70–1.40 | |||
| Group A | 1.09 (0.07) | 1.26 (0.09)† | 1.11 (0.08) | |
| Group B | 0.99 (0.04) | 1.03 (0.05)‡ | 1.13 (0.05)† | |
| CCR, mL/min | 90–140 | |||
| Group A | 82 (10) | 68 (8) | 79 (12) | |
| Group B | 115 (17) | 124 (29) | 89 (14)§ |
BMI = body mass index; SBP = systolic blood pressure; DBP = diastolic blood pressure; FPG = fasting plasma glucose; HbA1c = hemoglobin A1c; FFA = free fatty acid; FEUA = fractional excretion of uric acid; CCR = creatinine clearance rate.
∗
Patients in group A received fenofibrate for 8 weeks followed by placebo for 8 weeks, and group B received placebo followed by fenofibrate.
†
P<0.001 versus baseline.
‡
P<0.05 versus group A (Mann-Whitney U test).
§
P<0.01 versus baseline.
‖
P<0.001 versus group A (Mann-Whitney U test).
¶
P<0.05 versus baseline.
#
P<0.01 versus group A (Mann-Whitney U test).