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Analgesic effect of NT71 and NT72. Dose-dependent analgesia following topical instillation of (a) NT71 and (b) NT72 onto rabbit corneas, as assessed with esthesiometry. Significant dose dependence was found for NT71 and NT72 by 30 minutes of application. (c) Duration of analgesic effect using NT71 (1.5 mg/mL) and NT72 (1.0 mg/mL). NT71 induced analgesia for at least 150 minutes, while NT72 lasted at least 180 minutes. Results represent the mean of three independent replications.
