Table 1. Sequences of Hit Compounds from IgY Screen^a.

compound	X1b	R1c	X2b	R2c	X3b	R3c	X4b	R4c
1	S	Nmea	N	Nleu	N	Npip	N	Nlys
1	S	Nmea	N	Nleu	N	Npip	N	Nlys
1	S	Nmea	N	Nleu	N	Npip	N	Nlys
2	S	Nmea	N	Napp	N	Npip	N	Nlys
2	S	Nmea	N	Napp	N	Npip	N	Nlys
3	S	Napp	N	Npip	N	Npip	N	Nlys
3	S	Napp	N	Npip	N	Npip	N	Nlys
4	S	Npip	N	Nlys	N	Npip	N	Nlys
4	S	Npip	N	Nlys	N	Npip	N	Nlys
5	S	Nmea	N	Npip	N	Npip	N	Napp
6	N	Nlys	N	Napp	N	Npip	N	Nleu
7	N	Napp	N	Nmea	N	Npip	N	Nlys
8	N	Napp	N	Npip	N	Npip	N	Nlys
9	S	Nlys	N	Nleu	N	Npip	N	Nleu
10	S	Nlys	N	Napp	N	Npip	N	Nlys
11	S	Nlys	N	Nleu	N	Npip	N	Nlys
12	N	Nleu	N	Nlys	N	Npip	N	Nlys
13	N	Npip	N	Nlys	N	Npip	N	Nlys
14	S	Nmea	S	Nmea	N	Npip	N	Nlys
15	S	Npip	S	Nmea	N	Npip	N	Nlys
16	S	Nmea	N	Nleu	N	Npip	N	Nlys
17	N	Napp	R	Nmorph	N	Npip	N	Nlys
18	N	Nlys	N	Napp	N	Napp	N	Nlys
19	N	Nleu	N	Napp	N	Npip	N	Napp
20	S	Nmea	N	Npip	S	Nmea	N	Napp
21	N	Nlys	N	Npip	N	Npip	S	Nmoph
22	N	Napp	S	Nmea	N	Npip	N	Nlys
23	N	Nlys	N	Nleu	S	Nmorph	R	Nmorph

^aRepeat hits are highlighted in bold.

^bStereochemistry of α-methyl substituent, when present. N indicates the presence of achiral methylene (Figure 1C).

^cN-substituent side chains derived from the primary amines in Figure 1B.