Table 3.
Parameter definitions for base-case and sensitivity analyses of overdiagnosis model.
| Screening test | Mean sojourn time (years) | |||||||
|---|---|---|---|---|---|---|---|---|
| sensitivity (%) | 40 to 49 | 50-59 | ||||||
| Invasive | Invasive | In-situ | NPIS | PIS | PIBC | NPIS | PIS | PIBC |
| Base case | Median1 | Median | 3 | 0.175 | 1.825 | |||
| Long MST | Median | Upper limit2 | 5 | 0.25 | 2.75 | |||
| Short MST | Median | Lower limit3 | 2 | 0.1 | 1.5 | |||
| High sensitivity | 100 | 100 | Median | 3 | 0.175 | 1.825 | ||
| Low sensitivity | Lower limit | Median | 3 | 0.175 | 1.825 | |||
| Low sensitivity, long MST | Lower limit | Upper limit | 5 | 0.25 | 2.75 | |||
| High sensitivity, long MST | 100 | 100 | Upper limit | 5 | 0.25 | 2.75 | ||
1,2,3Refers to the median, upper limit, and lower limit of results from parameter estimation model, respectively. MST, median sojourn time; NPIC, non-progressive in situ; PIBC, preclinical invasive breast cancer; PIS, preclinical progressive in situ.