Table 1.

Basic characteristics of relatives and index patients from BRCA positive and negative families.

	Relatives of index patients	Index patients
Number of patients	6,235	6,230
Mutation status, number of patients
BRCA1 pathogenic mutation	213	1,154
BRCA2 pathogenic mutation	106	575
BRCA negative	4,326	4,501
not tested, BRCA1 family	1,046	-
not tested, BRCA2 family	544	-
Patients with contralateral breast cancer
patients from BRCA1 families	193	304
patients from BRCA2 families	56	84
patients from BRCA negative families	253	349
Median year of birth (IQR)
patients from BRCA1 families	1,943 (1933-1955)	1,960 (1952-1968)
patients from BRCA2 families	1,939 (1928-1952)	1,957 (1945-1965)
patients from BRCA negative families	1,936 (1926-1946)	1,955 (1944-1964)
Median age at first breast cancer (IQR)
patients from BRCA1 families	43.5 (37.5-51.5)	38.2 (32.8-44.4)
patients from BRCA2 families	48.1 (40.4-58.5)	42.5 (36.4-49.4)
patients from BRCA negative families	53.6 (45.3-63.9)	44.9 (37.9-51.4)
Median age at contralateral breast cancer (IQR)
patients from BRCA1 families	47.7 (40.1-55.5)	43.5 (37.7-50.5)
patients from BRCA2 families	53.1 (44.7-62.6)	47.9 (42.7-55.7)
patients from BRCA negative families	56.0 (48.5-66.6)	51.6 (45.3-59.0)

IQR, interquartile range.