Table 3.
Summary statistics of the reference values produced by three observers with the corresponding data of visual estimates and digital image analysis, n = 164
| Variable | Median | Mean | Std dev | Std error | Min | Max |
|---|---|---|---|---|---|---|
| Ki67-Count |
35.0 |
40.2 |
25.3 |
2.0 |
0.6 |
98.1 |
| Ki67-DIA-2 |
30.1 |
36.5 |
20.2 |
1.6 |
6.4 |
93.0 |
| Ki67-DIA-1 |
24.1 |
31.1 |
21.1 |
1.6 |
1.5 |
90.5 |
| Ki67-DIA-0 |
20.4 |
25.9 |
18.1 |
1.4 |
2.1 |
85.7 |
| Visual median |
30 |
37.2 |
27.4 |
2.1 |
2 |
95 |
| Visual mean |
28.4 |
36.2 |
25.6 |
2.0 |
2.2 |
96.4 |
| Ki67-VE-1 |
15 |
24.3 |
23.6 |
1.8 |
5 |
95 |
| Ki67-VE-2 |
40 |
43.4 |
29.6 |
2.3 |
2 |
98 |
| Ki67-VE-3 |
37.5 |
44.1 |
30.0 |
2.3 |
1 |
99 |
| Ki67-VE-4 |
22 |
31.6 |
24.3 |
1.9 |
1 |
95 |
| Ki67-VE-5 |
30 |
37.7 |
27.7 |
2.2 |
1 |
100 |
| Total profiles observer* |
2,372 |
2,658.7 |
1,390.4 |
108.6 |
464 |
7,452 |
| Total profiles DIA-2 |
2,150.5 |
2,293.2 |
796.8 |
62.2 |
752 |
4,302 |
| Total profiles DIA-1 |
1,920.5 |
2,022.7 |
670.1 |
52.3 |
1,012 |
3,788 |
| Total profiles DIA-0 | 4,203.5 | 4,385.0 | 1,420.2 | 110.9 | 1,640 | 7,939 |
*Total nuclear profiles observer counts are multiplied by four in this table to be comparable to the DIA total profile numbers (the box grid used for the observer count covers ne-fourth of the image area). DIA, digital image analysis; VE, visual estimate.