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. Author manuscript; available in PMC: 2014 Jun 11.
Published in final edited form as: Cancer Res. 2012 Sep 17;72(22):5702–5711. doi: 10.1158/0008-5472.CAN-12-1043

Figure 3.

Figure 3

Significant differential pathway activation in airway epithelial cells between smokers and non-smokers. A. Large airway epithelial cells from non-smokers (NS, n=13) and smokers (S, n=13) (GSE16008) hybridized to microarrays. SIRT1 was the only pathway that show a significant difference in pathway activation between the NS and S samples (SIRT1 pathway activation increased in S samples, p<0.001). B. Large airway epithelial cells from non-smokers (NS, n=22) and smokers (S, n=37) from dataset GSE10135. SIRT1 showed significant pathway activation (p=0.004) and IKBKB showed significant pathway de-activation in S samples (p=0.017). C. Large airway epithelial cells from non-smokers (NS, n=21), former smokers (FS, n=31) and smokers (S, n=52) from dataset GSE7895. SIRT1 showed significant pathway activation (p=0.001) and IKBKB showed significant pathway de-activation in S samples (p=0.021). C. Small airway epithelial cells from non-smokers (NS, n=38) and smokers (S, n=45) from dataset GSE11952. SIRT1 showed significant pathway activation (p=0.044), IKBKB showed significant pathway de-activation (p<0.001), and BCL2 showed significant pathway de-activation in S samples (p<0.001).