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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Front Biosci (Landmark Ed). 2014 Jan 1;19:566–570. doi: 10.2741/4227

Figure 4.

Figure 4

Signaling pathways mediating netrin-1 postconditioning induced cardioprotection. Differences in cardioprotective signaling pathways induced by netrin-1 postconditioning in DCC +/+ mice (A), compared to DCC +/− (B) mice. Our data have demonstrated roles of DCC, ERK1/2 and NO in mediating cardioprotection provoked by pharmacological postconditioning with netrin-1. Our previous findings have also established the sequence of activation for the signaling components involved, namely a DCC-ERK1/2-NO cascade8. Absence of DCC in the DCC+/− mice leads to lack of activation in ERK1/2 and NO, resulting in diminished cardioprotection in response to netrin-1.