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Diagram representing how the combined metabolism of the three compounds could induce the responses observed. After one-day treatments, GSTT1 and CYP2E1 induction could contribute to the generation of metabolites and ROS to produce increased MNPCE. After three-day treatments, still induced CYP2E1 and reduced activity of antioxidant enzymes (empty arrows) lead to the accumulation of H2O2 and the superoxide anion, damaging membranes and allowing an oxidative stress.
