Table 1.
Acute toxic effects in rodent i.p. exposed to dichloromethane (DCM), chloroform (CLF) or toluene (TOL).
| VOC | Dose (mmol/kg) | P-450 | CYP2E1 | Lipid peroxidation | GSH | MNPCE | CA | Reference |
|---|---|---|---|---|---|---|---|---|
| DCM | 2.5 | 0 | 0 | 0 | 0 | Pilot study | ||
| CLF | 2.6 | 0 | +0.48 | 0 | 0 | Pilot study | ||
| TOL | 8 | −0.48 | +0.50 | 0 | 0 | Pilot study | ||
|
| ||||||||
| DCM | 1.2–2.4 | 0 | 0 | [23] | ||||
| 4.8–9.5 | +0.4–0.50 | +0.35 | [23] | |||||
| 6 | 0 | [24] | ||||||
| 5–20 | 0 | [25] | ||||||
| 1.2–23.5 | 0 | [26] | ||||||
|
| ||||||||
| CLF | 0.1 | 0 | [27] | |||||
| 1.3 | 0 | 0 | 0 | [28] | ||||
| 1.7 | −0.07 | [27] | ||||||
| 2.0–8.0 | 0 | [25] | ||||||
| 0.01 | +3.75 | [21] | ||||||
| 0.1–1.0 | +7.75 | [21] | ||||||
|
| ||||||||
| TOL | 5 | 0 | +1.16 | [29] | ||||
| 5.4 | 0 | [9] | ||||||
| 10.8 | +0.30 | [9] | ||||||
| 16.2 | +0.17 | [9] | ||||||
| 20 | 0 | [30] | ||||||
| 1.2 | 0 | 0 | [31] | |||||
| 2.4 | +0.32 | 0 | [31] | |||||
| 4.7 | 0 | +2.71 | [31] | |||||
Data represent significant fold increases (+) or decreases (−) with respect to control animals; zero means no change.
Cytochrome P450 (P-450), cytochrome 2E1 (CYP2E1), lipid peroxidation and glutathione (GSH) were determined in liver, micronuclei (MNPCE) and chromosomal aberrations (CA) were determined in bone marrow.